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Menu Infarmed, área de documentação e informação, acesso à área de circulares The most potent ionic liquid was the laurate salt of chloroquine , which presented IC 50 values of 4 and 110 nM against a chloroquine -sensitive and a chloroquine -resistant strain of Plasmodium falciparum, respectively, corresponding to an 11-and 6-fold increase in potency as compared to the reference chloroquine bisphosphate salt against the This inhibition decreased when the drug was added from 1 h to 4 h after infection Chloroquine had no direct effect on the virus nor on viral adsorption and internalization Electron microscopy showed that, in the presence of the drug, the virions were retained in large vacuoles having a lysosomal appearance Dependence of Viscosity and Diffusion on β-Cyclodextrin and Chloroquine Diphosphate Interactions: Authors: Musilová, Lenka Mráček, Aleš novaresearch unl pt effect-of-chloroquine-on-the-expression-of-genes-invo Chloroquine has been described to increase Plasmodium infectivity to the mosquito vector and is known to affect the vertebrate host immune response including during malarial infection Although knowledge of the mosquito immune response has recently improved, nothing is known about the impact of chloroquine on mosquito immunity Continuous removal of pharmaceutical drug chloroquine and Safranin-O dye from water using agar-graphene oxide hydrogel: Selective adsorption in batch and fixed-bed Keywords: chloroquine diphosphate; diffusion; drugs; solutions; transport properties 1 Introduction Chloroquine diphosphate (CDP) is a 4-aminoquinoline-based drug with a broad spectrum of applications, including all types of malaria infections and averse to cell growth and or inducing cell death in human leukemia K562 cell [1–3] novaresearch unl pt the-effect-of-chloroquine-on-the-production-of-interf Building on Surface-Active Ionic Liquids for the Rescuing of the Antimalarial Drug Chloroquine: Autor: Silva, Ana Teresa Lis, Lobo Oliveira, Isabel S Gomes, Joana Teixeira, Cátia Nogueira, Fátima Marques, Eduardo F Ferraz, Ricardo Gomes, Paula: Palavras-chave: Antimalarial Chloroquine Ionic liquid Malaria Rescuing Repurposing Surface active derived from chloroquine and natural fatty acids whose antimalarial activity in vitro was found to be superior to that of the parent drug The most potent ionic liquid was the laurate salt of chloroquine, which presented IC50 values of 4 and 110 nM against a chloroquine-sensitive and aThe most potent ionic liquid was the laurate salt of chloroquine, which presented IC 50 values of 4 and 110 nM against a chloroquine-sensitive and a chloroquine-resistant strain of Plasmodium falciparum, respectively, corresponding to an 11-and 6-fold increase in potency as compared to the reference chloroquine bisphosphate salt against the The effect of chloroquine (CQ) on the production pattern of interferon (IFN)-γ, interleukin (IL)-4, IL-6, and IL-10 in female C57BL6 mice infected with Plasmodium chabaudi chabaudi AS was evaluated during a period of 35 days Our data confirm that there is a switch from a T helper cell (Th)1 to a Th2 response during malaria infection in this Dependence of Viscosity and Diffusion on β-Cyclodextrin and Chloroquine Diphosphate Interactions: Authors: Musilová, Lenka Mráček, Aleš estudogeral uc pt Dependence-of-viscosity-and-diffusion-on-cyclodextrin-a Building on surface-active ionic liquids for the rescuing of the antimalarial drug chloroquine: Autor: Silva, Ana Teresa Lobo, Lis Oliveira, Isabel S Gomes, Joana Teixeira, Cátia Nogueira, Fátima Marques, Eduardo F Ferraz, Ricardo Gomes, Paula: Palavras-chave: Antimalarial Chloroquine Ionic liquid Malaria Repurposing Rescuing Surface activerun unl pt Effect_of_chloroquine_on_gene_expression_of_Plasmodium_yoelii pdfnovaresearch unl pt building-on-surface-active-ionic-liquids-for-the-resc estudogeral uc pt handle 10316 105414recipp ipp pt bitstream 10400 22 16528 1 ART_Ricardo_Ferraz pdfrepositorio ul pt handle 10451 28750recipp ipp pt handle 10400 22 16528associated chloroquine treatment with increased infectiv-ity of drug-resistant parasites to the mosquito Later, Hogh et al [2] reported that mosquitoes fed with Plasmodium falciparum or Plasmodium berghei gametocytes in the pres-ence of serum from chloroquine-treated human volun-teers showed four to five fold increase in the mean oocyst derived from chloroquine and natural fatty acids whose antimalarial activity in vitro was found to be superior to that of the parent drug The most potent ionic liquid was the laurate salt of chloroquine , which presented IC50 values of 4 and 110 nM against a chloroquine -sensitive and a run unl pt handle 10362 116628The effect of chloroquine (CQ) on the production pattern of interferon (IFN)-γ, interleukin (IL)-4, IL-6, and IL-10 in female C57BL6 mice infected with Plasmodium chabaudi chabaudi AS was evaluated during a period of 35 days Our data confirm that there is a switch from a T helper cell (Th)1 to a Th2 response during malaria infection in this compras online ; 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